Journal article
Links between copper and cholesterol in Alzheimer's disease
YH Hung, AI Bush, SL Fontaine
Frontiers in Physiology | FRONTIERS MEDIA SA | Published : 2013
Abstract
Altered copper homeostasis and hypercholesterolemia have been identified independently as risk factors for Alzheimer's disease (AD). Abnormal copper and cholesterol metabolism are implicated in the genesis of amyloid plaques and neurofibrillary tangles (NFT), which are two key pathological signatures of AD. Amyloidogenic processing of a sub-population of amyloid precursor protein (APP) that produces Aβ occurs in cholesterol-rich lipid rafts in copper deficient AD brains. Co-localization of Aβ and a paradoxical high concentration of copper in lipid rafts fosters the formation of neurotoxic Aβ:copper complexes. These complexes can catalytically oxidize cholesterol to generate H2O2, oxysterols ..
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Funding Acknowledgements
This work was supported by funding from the National Health and Medical Research Council of Australia (Ashley I. Bush. and Sharon La Fontaine.), Cooperative Research Centre for Mental Health (Ashley I. Bush), the Addi and Cassi Fund (Ashley I. Bush and Ya Hui Hung), Perpetual Trustees (Harry Secomb Foundation and Payne L & Heather Medical Research Charitable Foundation; Ashley I. Bush). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.